Friday, February 27, 2015

Breakthrough in understanding how cancer cells metastasize

This study is based on mice. It might be a breakthrough.

Date: February 27, 2015


A protein commonly found in human cells could be an important switch that activates cancer cell metastasis, according to a new study. The finding focuses attention on a biological mechanism that until now was largely overlooked. The discovery of the protein's effect significantly expands our understanding of epithelial cancers such as breast and lung cancer.


 M. S. Ioannou, E. S. Bell, M. Girard, M. Chaineau, J. N. R. Hamlin, M. Daubaras, A. Monast, M. Park, L. Hodgson, P. S. McPherson. DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior. The Journal of Cell Biology, 2015; 208 (5): 629 DOI: 10.1083/jcb.201407068

No comments: