Sunday, January 4, 2015

Cannabis extracts effective against glioblastoma (brain tumours) in mice

The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model

A widely publicised study of the effect of cannabinoids THC and CBD shows that, when combined with radiotherapy, they can cause glioblastoma to grow significantly slower in mice. Treated animals’ tumours were nine times smaller with treatment after three weeks. The authors conclude cannabinoids may sensitise glioblastoma cells to radiation. Read more.
"Taken together, our data highlight the possibility that these cannabinoids can prime glioma cells to respond better to ionizing radiation, and suggest a potential clinical benefit for glioma patients by using these two treatment modalities. Mol Cancer Ther; 1–13. ©2014 AACR."

Liu’s study  in mice models found THC and CBD, when used together, helped shrink the tumors to a far greater extent than radiation and just one of the compounds or radiation alone, which actually yielded a negligible effect on tumor growth. What’s more, the team needed a smaller dosage of each substance when they were used together in order to kill 50 percent of the cancer cells. They needed 14 millimolar (a unit of concentration) of CBD and 19 millimolar of THC. Using both, they needed only seven millimolars each.

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